PharmaStar

This task aims to map the species of interest using remote sensing data and digital image processing tools, including statistical and/or machine learning methods

In this task a comprehensive review of the medicinal applications of PNSE plants in the prevention and treatment of Diabetes Mellitus will be conducted. Promising plants and phytochemicals will be identified through bibliographic research to inform subsequent tasks.

This task will involve the collection of a diverse array of plant material, encompassing roots, stems, leaves, and berries from various plants within the PNSE (e.g. carqueja, cistus, juniper, elderberry). A similar procedure will be followed with the plant matrices intended for use as excipients, including acorns and propolis.

The antidiabetic potential of plant extracts will be screened via spectrophotometric analysis of glucosidase and amylase inhibition. Selected extracts will undergo chemical characterization (HPLC, GC-MS) and interaction studies (Docking, MD). Cell viability and toxicity will be assessed using MTT, SRB, and LDH assays on intestinal and liver cell models.

This task will look for the optimization of solid pharmaceutical forms with plant extracts and natural polymers for antidiabetic activity. Formulations will combine commercial drugs with extracted compounds for synergy. Particles from acorn and propolis will be produced. Bio-accessibility and bio-availability will be tested in vitro, including assays on animal tissues.

Assess the pharmaceutical formulations' potential for type II diabetes control through in vitro, in vivo, and preliminary clinical trials with APDP support.

The aim of this task is two-fold: assure the effective implementation of the project and preparation of a roadmap for the development of the region based on the knowledge and technology developed.